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[Music] the uses of estrogen hormone replacement therapy have changed a lot since it was first discovered believe it or not the first preparations to be approved by the FDA and then popularized came from horse urine it’s even still in use today and is called Premarin after pregnant me urine there was a huge spike in use in postmenopausal women in the’ 60s on the back of the feminist movement and Dr Wilson’s book feminine forever where he described menopause as a hormone deficiency that should be treated for the rest of women’s life in the’ 70s zealong colleagues however discovered that having estrogen without progesterone actually increases their risk of endometrial cancer plummeting hrt’s use with a greater understanding of its breast cancer and cardiovascular risks it’s been slowly growing in use again since then more recent years specifically amongst the trans Community what concerns would you have …